The fatigue I was describing to my GobyMeds provider sounded embarrassing out loud. I was sleeping 7 hours. I wasn’t overworking. I was eating reasonably, down 19 pounds on GLP-1, and still dragging myself through afternoons like I was running on fumes.
She didn’t dismiss it. She said it was common among women in their mid to late forties, even women doing everything right. Then she mentioned NAD+.
Why I Decided to Try It
My first reaction was skepticism. I’d heard NAD+ mentioned in biohacking circles and assumed it was in the same category as expensive supplements that work for 25-year-old athletes and nobody else.
What changed my mind was the mechanism. NAD+ isn’t a stimulant. It’s not a hormone. It’s a coenzyme your body already makes and uses constantly for cellular energy production. After 45, your levels drop significantly. You’re not imagining the fatigue. Your cells are running with less of the fuel they need.
That made sense to me in a way that “try this supplement for energy” never had before.
The Process Through GobyMeds
I already had a relationship with GobyMeds through my GLP-1 prescription, so adding NAD+ was straightforward. I answered some additional health questions, had a brief consultation, and was approved. The injections are subcutaneous, similar to GLP-1, so there was no new learning curve on administration.
What I Noticed
I want to be careful here because I was making other changes at the same time. I can’t tell you with certainty that NAD+ caused every shift I noticed. What I can tell you is what happened.
By week two, my afternoon energy was better. Not dramatically, but noticeably. The 2pm wall that I had normalized just wasn’t as steep.
By week four, my workouts felt less like punishment. Recovery between sessions improved. I was waking up feeling more rested even when my sleep hours hadn’t changed.
The cognitive piece surprised me most. I noticed I was staying focused on tasks longer without the mental drift that had become my baseline. Whether that’s NAD+, the weight loss itself, better sleep, or some combination, I can’t say for certain. But the timing aligned.
What Didn’t Change
It didn’t fix everything. My motivation on hard days still requires actual motivation. Energy levels still fluctuate. I still have bad weeks.
NAD+ isn’t a personality transplant. It’s more like removing a ceiling you didn’t know was there. The work is still yours to do.
Is It Worth It?
For me, yes. I was already taking GLP-1 seriously, already working on the fundamentals. NAD+ felt like the piece that addressed something the other interventions weren’t reaching.
If you’re younger and your energy is genuinely fine, it probably isn’t the right priority. If you’re in your 40s or 50s, doing everything right, and still feeling like you’re running below capacity, it’s worth asking your provider about.
GobyMeds is where I get mine. Use code MTVN25 for $25 off your first order. I earn a commission if you use that link.
Judy White is the founder of Motivation Weight Loss. She writes from personal experience and is not a medical professional.